Cradd Gene Summary [Mouse]
Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cradd |
| Official Name | CASP2 and RIPK1 domain containing adaptor with death domain [Source:MGI Symbol;Acc:MGI:1336168] |
| Ensembl ID | ENSMUSG00000045867 |
| Bio databases IDs | |
| Aliases | CASP2 and RIPK1 domain containing adaptor with death domain |
| Synonyms | CASP2 and RIPK1 domain containing adaptor with death domain, MRT34, RAIDD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cradd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Caspase recruitment domain
- protease binding
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Cradd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypertension
- autosomal recessive mental retardation with variant lissencephaly 34
- mental retardation
- fracture of bone
- osteoarthritis
- idiopathic scoliosis
- male pattern hair loss
- syndromic mental retardation
- nonsyndromic arrhythmogenic right ventricular cardiomyopathy
role in cell
- expression in
- apoptosis
- binding in
- polymerization in
- cytostasis
- disruption
- sensitivity
- disruption in
- endothelial barrier function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cradd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- positive regulation of apoptotic process
- apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- induction of apoptosis via death domain receptors
- response to DNA damage stimulus
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- protease binding
- protein binding, bridging
- death domain binding