Pilra Gene Summary [Mouse]
Predicted to enable MHC class I protein binding activity. Predicted to act upstream of or within signal transduction. Predicted to be located in cell periphery and membrane. Is expressed in heart ventricle; lung; and urethra. Orthologous to several human genes including PILRA (paired immunoglobin like type 2 receptor alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pilra |
| Official Name | paired immunoglobin-like type 2 receptor alpha [Source:MGI Symbol;Acc:MGI:2450529] |
| Ensembl ID | ENSMUSG00000046245 |
| Bio databases IDs | |
| Aliases | paired immunoglobin-like type 2 receptor alpha |
| Synonyms | FDF03, paired immunoglobin-like type 2 receptor alpha, paired immunoglobin-like type 2 receptor α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pilra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- protein binding
- cytosolic tail domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatomegaly
- age-related macular degeneration
- Alzheimer disease
- hepatic fibrosis
- arthritis
- bleeding
role in cell
- number
- adhesion
- migration
- function
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pilra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- MHC class I protein binding