Adap1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity; inositol 1,3,4,5 tetrakisphosphate binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in nervous system. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Adap1 |
| Official Name | ArfGAP with dual PH domains 1 [Source:MGI Symbol;Acc:MGI:2442201] |
| Ensembl ID | ENSMUSG00000056413 |
| Bio databases IDs | |
| Aliases | ArfGAP with dual PH domains 1 |
| Synonyms | 4930431P11Rik, ArfGAP with dual PH domains 1, CENTA1, CENTAURIN alpha1, GC1L, GCS1L, IP4 receptor, p42IP4, Pip3bp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Putative GTP-ase activating proteins for the small GTPase, ARF
- PH domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrioma
- inflammatory bowel disease
- hypertension
- Crohn disease
role in cell
- expression in
- activation in
- binding in
- generation in
- phosphorylation in
- generation
- density
- reactivation in
- structural plasticity
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of GTPase activity
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- metal ion binding
- GTPase activator activity
- inositol 1,3,4,5 tetrakisphosphate binding