Muc16 Gene Summary [Mouse]
Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc16 |
| Official Name | mucin 16 [Source:MGI Symbol;Acc:MGI:1920982] |
| Ensembl ID | ENSMUSG00000109564 |
| Bio databases IDs | |
| Aliases | mucin 16 |
| Synonyms | 1110008I14Rik, CA125, Gm1480, Gm21044, LOC100293231, LOC100508913, LOC101060361, LOC686731, Muc16l, mucin 16, mucin 16, cell surface associated, RGD1308422 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- SEA domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- liver cancer
- COVID-19
- ovarian carcinoma
- epithelial ovarian cancer
- B-cell non-Hodgkin disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- peritoneal adenocarcinoma
- peritoneal endometrioid adenocarcinoma
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- binding
- G2/M phase
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Golgi lumen
- extracellular vesicles
- cell surface
- Extracellular Space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- vesicle
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding