Bmpr1b Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; BMP binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including BMP signaling pathway; ovarian cumulus expansion; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within several processes, including cartilage development; neuron differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in acromesomelic dysplasia 3; brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmpr1b |
| Official Name | bone morphogenetic protein receptor type 1B [Source:RGD Symbol;Acc:1595863] |
| Ensembl ID | ENSRNOG00000016289 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein receptor type 1B |
| Synonyms | Acvrlk6, ALK-6, AMD3, AMDD, AV355320, BDA1D, BDA2, BMPR-IB, bone morphogenetic protein receptor type 1B, bone morphogenetic protein receptor, type 1B, CDw293, CFK-43a, LOC684964, LOC687473, SKR6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmpr1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- extracellular domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Activin types I and II receptor domain
- cytokine binding
- Protein tyrosine and serine/threonine kinase
- ectodomain
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- TRAF6 binding domain
- Serine/Threonine protein kinases, catalytic domain
- transforming growth factor-beta receptor
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein serine/threonine kinase
- type I transforming growth factor-beta receptor
- TFP
- Tyrosine kinase, catalytic domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Bmpr1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- NF-κB Signaling
- PTEN Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
- TGF-β Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- breast cancer
- tumorigenesis
- schizophrenia
- hypertension
- renal clear cell adenocarcinoma
- renal clear cell cancer
- brachydactyly
- brachyphalangia
- metabolic syndrome X
role in cell
- proliferation
- quantity
- apoptosis
- adipogenesis
- differentiation
- maturation
- signaling in
- contact growth inhibition
- expansion
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmpr1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cartilage development
- retinal ganglion cell axon guidance
- retina development in camera-type eye
- endochondral bone morphogenesis
- chondrocyte development
- central nervous system neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- protein phosphorylation
- ovulation cycle
- ovarian cumulus expansion
- dorsal/ventral pattern formation
- eye development
- inflammatory response
- cartilage condensation
- cellular response to BMP stimulus
- positive regulation of gene expression
- cellular response to growth factor stimulus
- BMP signaling pathway
- osteoblast differentiation
- proteoglycan biosynthetic process
- positive regulation of chondrocyte differentiation
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- dendrite
- receptor complex
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- BMP binding
- ATP binding
- transmembrane signaling receptor activity
- protein binding
- SMAD binding
- metal ion binding
- protein serine/threonine kinase activity
- transforming growth factor beta receptor activity, type I
- transmembrane receptor protein serine/threonine kinase activity