Wnt3 Gene Summary [Rat]
Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including limb bud formation; midbrain dopaminergic neuron differentiation; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of extent of cell growth. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt3 |
| Official Name | Wnt family member 3 [Source:RGD Symbol;Acc:3972] |
| Ensembl ID | ENSRNOG00000003845 |
| Bio databases IDs | |
| Aliases | Wnt family member 3 |
| Synonyms | INT4, TETAMS, wingless-type MMTV integration site family, member 3, Wnt5, Wnt family member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- protein domain specific binding
- receptor agonist activity
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- schizophrenia
- rheumatoid arthritis
- chronic myeloid leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- neoplasia
- squamous cell lung cancer
- neuroticism
- brain cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- growth
- activation in
- formation
- proliferation
- quantity
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endocytic vesicle membrane
- Plasma Membrane
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Spemann organizer formation at the anterior end of the primitive streak
- axon guidance
- gamete generation
- dorsal/ventral axis specification
- positive regulation of osteoblast differentiation
- head morphogenesis
- canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
- anterior/posterior axis specification
- regulation of mesenchymal stem cell differentiation
- stem cell proliferation
- mammary gland epithelium development
- canonical Wnt receptor signaling pathway
- mesoderm formation
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- neuron differentiation
- cell morphogenesis
- limb bud formation
- negative regulation of axon extension involved in axon guidance
- cellular response to retinoic acid
- positive regulation of collateral sprouting in absence of injury
- positive regulation of gene expression
- cell fate commitment
- gene expression
- positive regulation of Wnt receptor signaling pathway
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- Golgi lumen
- extracellular region
- plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein domain specific binding
- protein binding
- receptor agonist activity
- cytokine activity