Gnal Gene Summary [Rat]
Predicted to enable G protein activity; G protein-coupled receptor binding activity; and G-protein beta/gamma-subunit complex binding activity. Involved in cellular response to dopamine and regulation of long-term synaptic depression. Located in acrosomal vesicle; apical cytoplasm; and sperm midpiece. Part of ciliary necklace. Used to study dystonia. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in dystonia 25. Orthologous to human GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnal |
| Official Name | G protein subunit alpha L [Source:RGD Symbol;Acc:2715] |
| Ensembl ID | ENSRNOG00000010440 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha L |
| Synonyms | 2610011C15RIK, 9630020G10RIK, Adenylate cyclase-stimulating g alpha, Adenylate cyclase-stimulating g α, AI843190, DYT25, Galphaolf, G(alpha)olf, Gna10, Golf, G Protein Alpha S/Olf, G protein subunit alpha L, G protein subunit α L, G protein α -olf, G Protein α S/Olf, guanine nucleotide binding protein, alpha stimulating, olfactory type, guanine nucleotide binding protein, α stimulating, olfactory type, G α olf, G(α)olf, HG1O, Olf, RGD1305940 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gnal often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- small monomeric GTPase
- GTPase
- G-protein alpha subunit
- enzyme
- protein binding
- enzyme regulator activity
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Gnal gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CDK5 Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- GABA Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Huntington disease
- torsion dystonia
- dystonia type 25
- dystonia
- nicotine dependence
- HER2 negative hormone receptor negative breast cancer
- alcoholism
role in cell
- apoptosis
- differentiation
- invasion
- response by
- length
- excitation in
- firing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cellular membrane
- Plasma Membrane
- apical cytoplasm
- olfactory cilia
- sperm midpiece
- sperm tail
- acrosome
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gnal gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-activating dopamine receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- heterotrimeric G-protein complex
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- protein binding
- metal ion binding
- GTPase activity
- G-protein beta/gamma-subunit complex binding