Tmprss4 Gene Summary [Rat]
Predicted to enable serine-type peptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within negative regulation of growth rate; regulation of gene expression; and response to wounding. Predicted to be located in extracellular space and secretory granule. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss4 |
| Official Name | transmembrane serine protease 4 [Source:RGD Symbol;Acc:1305033] |
| Ensembl ID | ENSRNOG00000026650 |
| Bio databases IDs | |
| Aliases | transmembrane serine protease 4 |
| Synonyms | CAP2, CAPH2, LOC683941, mCAP2, MT-SP2, TMPRSS3, transmembrane protease, serine 4, transmembrane serine protease 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmprss4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- LDLa
- Domain of unknown function (DUF1986)
- Trypsin-like peptidase domain
- protein binding
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Tmprss4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- organismal death
- gastric cancer
role in cell
- growth
- expression in
- anoikis
- gefitinib sensitivity
- invasion
- migration
- spreading in
- molecular cleavage in
- oxaliplatin sensitivity
- gemcitabine sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmprss4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- response to wounding
- regulation of gene expression
- protein processing
- positive regulation of viral entry into host cell
- negative regulation of growth rate
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity