Pde1b Gene Summary [Rat]
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling; cellular response to cytokine stimulus; and monocyte differentiation. Predicted to act upstream of with a positive effect on dopamine catabolic process. Predicted to act upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Located in neuronal cell body. Biomarker of Parkinsonism. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde1b |
| Official Name | phosphodiesterase 1B [Source:RGD Symbol;Acc:3278] |
| Ensembl ID | ENSRNOG00000036828 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 1B |
| Synonyms | Aop2, CaM-PDE, HEL-S-79p, PDE1B1, PDES1B, phosphodiesterase 1B, phosphodiesterase 1B, Ca2+-calmodulin dependent |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cyclic-nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- cAMP-specific phosphodiesterase
- calcium/calmodulin-regulated cGMP-specific phosphodiesterase
- 3'5'-cyclic nucleotide phosphodiesterase N-terminal
- enzyme
- protein binding
- HDc
- calmodulin-dependent cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- preeclampsia
- hyperactive behavior
- experimentally-induced diabetes
- deep vein thrombosis
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- serotonin metabolic process
- locomotory behavior
- response to amphetamine
- dopamine catabolic process
- visual learning
- monocyte differentiation
- cellular response to macrophage colony-stimulating factor stimulus
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
- calmodulin binding
- protein binding
- metal ion binding
- calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity