Pde1c Gene Summary [Rat]
Enables cAMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde1c |
| Official Name | phosphodiesterase 1C [Source:RGD Symbol;Acc:68332] |
| Ensembl ID | ENSRNOG00000012337 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 1C |
| Synonyms | cam-PDE 1C, DFNA74, hCam-3, phosphodiesterase 1C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- 3',5'-cAMP binding
- cAMP-specific phosphodiesterase
- calcium/calmodulin-regulated cGMP-specific phosphodiesterase
- 3'5'-cyclic nucleotide phosphodiesterase N-terminal
- enzyme
- HDc
- calmodulin-dependent cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde1c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- autosomal dominant deafness type 74
- abdominal aortic aneurysm
- nicotine dependence
- neuroticism
- corneal neovascularization
- Moyamoya disease
- coronary artery disease
role in cell
- expression in
- formation
- senescence
- sphere formation
- formation in
- store-operated calcium influx in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell leading edge protrusion
- cilia
- lysosome
- cytosol
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuronal cell body
- lysosome
Molecular Function
What the gene product does at the molecular level
- calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
- calmodulin binding
- metal ion binding
- calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity