Pde1a Gene Summary [Rat]
Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in neuronal cell body. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde1a |
| Official Name | phosphodiesterase 1A [Source:RGD Symbol;Acc:68329] |
| Ensembl ID | ENSRNOG00000054212 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 1A |
| Synonyms | 3-RACEclone8phosphodiesterase1A, 3'-RACEclone8phosphodiesterase1A, CAM-PDE-1A, Cam Pde61, HCAM-1, HSPDE1A, LOC102554725, PDE1, phosphodiesterase 1A, phosphodiesterase 1A, calmodulin-dependent |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- cAMP-specific phosphodiesterase
- calcium/calmodulin-regulated cGMP-specific phosphodiesterase
- 3'5'-cyclic nucleotide phosphodiesterase N-terminal
- enzyme
- protein binding
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
- calmodulin-dependent cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- myocardial infarction
- major depression
- gout
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Alzheimer disease
- spermatocele
- coronary artery disease
- endometriosis
role in cell
- phosphorylation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- sperm tail
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of smooth muscle cell proliferation
- regulation of smooth muscle cell apoptotic process
- cGMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
- calmodulin binding
- metal ion binding
- calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity