Terc Gene Summary [Mouse]
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Terc |
| Official Name | telomerase RNA component [Source:MGI Symbol;Acc:MGI:109558] |
| Ensembl ID | ENSMUSG00000118406 |
| Bio databases IDs | |
| Aliases | telomerase RNA component |
| Synonyms | DKCA1, hTR, LOC100133738, mTER, mTR, PFBMFT2, SCARNA19, telomerase RNA component, TELOMERASE VERT, TER, TR, TRC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Terc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- enzyme binding
- protein domain specific binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- anemia
- epithelial neoplasia
- epithelial cancer
- neoplasia
- prostate cancer
- colorectal cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
phenotypes
- abnormal DNA repair
- abnormal adipose tissue distribution
- abnormal angiogenesis
- abnormal bone marrow morphology
- abnormal bone ossification
- abnormal cardiac muscle contractility
- abnormal cardiac muscle relaxation
- abnormal cardiovascular system physiology
- abnormal cell physiology
- abnormal chromosome morphology
- abnormal compact bone morphology
- abnormal developmental patterning
- abnormal enterocyte proliferation
- abnormal female meiosis
- abnormal fetal cardiomyocyte proliferation
- abnormal intestine morphology
- abnormal male germ cell apoptosis
- abnormal male meiosis
- abnormal meiosis
- abnormal myocardial fiber morphology
- abnormal oocyte morphology
- abnormal osteoid morphology
- abnormal skeleton physiology
- abnormal spermatid morphology
- abnormal spermatocyte morphology
- abnormal spleen B cell follicle morphology
- abnormal telomere length
- alopecia
- cardiac hypertrophy
- chromosomal instability
- congestive heart failure
- decreased B cell proliferation
- decreased T cell proliferation
- decreased body size
- decreased body weight
- decreased bone trabecula number
- decreased bone volume
- decreased compact bone area
- decreased compact bone thickness
- decreased fetal size
- decreased heart left ventricle weight
- decreased heart weight
- decreased incidence of induced tumors
- decreased incidence of tumors by chemical induction
- decreased left ventricle developed pressure
- decreased litter size
- decreased myocardial fiber number
- decreased spleen germinal center number
- decreased telomere length
- decreased trabecular bone thickness
- dilated cardiomyopathy
- heart left ventricle hypertrophy
- hypoactivity
- increased B cell apoptosis
- increased apoptosis
- increased bone trabecular spacing
- increased cardiomyocyte apoptosis
- increased embryonic tissue cell apoptosis
- increased enterocyte apoptosis
- increased left ventricle diastolic pressure
- increased lymphoma incidence
- infertility
- kyphosis
- open neural tube
- osteoporosis
- premature aging
- premature death
- prenatal lethality incomplete penetrance
- reduced female fertility
- testicular atrophy
- weight loss
role in cell
- binding in
- quantity
- expression in
- apoptosis
- phosphorylation in
- interaction in
- invasion by
- activation in
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Cajal bodies
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Terc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere maintenance via telomerase
- cellular response to hypoxia
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- cytoplasm
- Cajal body
- telomerase holoenzyme complex
- telomerase catalytic core complex
Molecular Function
What the gene product does at the molecular level
- telomerase activity
- telomeric template RNA reverse transcriptase activity
- RNA-directed DNA polymerase activity
- DNA polymerase binding
- protein binding
- WD40-repeat domain binding
- template for synthesis of G-rich strand of telomere DNA activity