Nos2 Gene Summary [Mouse]
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Nos2 |
| Official Name | nitric oxide synthase 2, inducible [Source:MGI Symbol;Acc:MGI:97361] |
| Ensembl ID | ENSMUSG00000020826 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase 2, inducible |
| Synonyms | CALCIUM-INDEPENDENT NOS, Hepatocyte NOS, HEP-NOS, Inducible NOS, INOS, LOC497963, MAC-NOS, nitric oxide synthase 2, nitric oxide synthase 2, inducible, NOS, NOS2A, NOS-II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nos2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- FAD binding domain
- Nitric oxide synthase, oxygenase domain
- heat shock protein binding
- enzyme
- identical protein binding
- NADPH-dependent FMN reductase
- NOS_oxygenase
- NADP binding
- FMN binding
- actin binding
- cadherin binding
- oxygenase domain
- flavin adenine dinucleotide binding
- protein kinase binding
- calmodulin binding
- beta-catenin binding
- calmodulin binding domain
- nitric-oxide synthase
- enzyme binding
- flavodoxin
- heme binding domain
- protein binding
- heme binding
- cAMP-dependent protein kinase regulator
- amino acid binding
- reductase domain
- binding protein
- protein homodimerization
- active site
- PDZ binding motif
- Oxidoreductase NAD-binding domain
Pathways
Biological processes and signaling networks where the Nos2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Colorectal Cancer Metastasis Signaling
- Corticotropin Releasing Hormone Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- ILK Signaling
- iNOS Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MSP-RON Signaling Pathway
- Neuroinflammation Signaling Pathway
- Osteoarthritis Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Relaxin Signaling
- Role of IL-17A in Arthritis
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- congestive heart failure
- neoplasia
- colon adenocarcinoma
- hypertension
- glioblastoma
- metastasis
- allodynia
- primary open-angle glaucoma
- experimental autoimmune encephalomyelitis
phenotypes
- abnormal T-helper 1 physiology
- abnormal adaptive immunity
- abnormal adrenocorticotropin level
- abnormal blood circulation
- abnormal blood coagulation
- abnormal blood homeostasis
- abnormal bone healing
- abnormal bone mineralization
- abnormal bone structure
- abnormal brain wave pattern
- abnormal cardiovascular system morphology
- abnormal cardiovascular system physiology
- abnormal circadian sleep/wake cycle
- abnormal circulating estradiol level
- abnormal circulating glucose level
- abnormal circulating serum albumin level
- abnormal corpus callosum morphology
- abnormal digestion
- abnormal eating behavior
- abnormal enzyme/coenzyme level
- abnormal eosinophil cell number
- abnormal fertilization
- abnormal frequency of paradoxical sleep
- abnormal gametogenesis
- abnormal glucose homeostasis
- abnormal heart morphology
- abnormal heart right ventricle pressure
- abnormal heart ventricle morphology
- abnormal homeostasis
- abnormal hormone level
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal induced retinal neovascularization
- abnormal inflammatory response
- abnormal involution of the mammary gland
- abnormal macrophage physiology
- abnormal male meiosis
- abnormal mammary gland physiology
- abnormal motor capabilities/coordination/movement
- abnormal myocardium layer morphology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal peripheral nervous system regeneration
- abnormal physiological neovascularization
- abnormal platelet aggregation
- abnormal platelet physiology
- abnormal reproductive system morphology
- abnormal respiratory bronchiole morphology
- abnormal respiratory system physiology
- abnormal response to infection
- abnormal response to tactile stimuli
- abnormal sensory capabilities/reflexes/nociception
- abnormal sleep pattern
- abnormal surfactant physiology
- abnormal systemic arterial blood pressure
- abnormal testis morphology
- abnormal thermal nociception
- abnormal tooth hard tissue morphology
- abnormal trabecular bone morphology
- abnormal uterine artery morphology
- abnormal uterus morphology
- abnormal vitreous body morphology
- allodynia
- altered tumor susceptibility
- atherosclerotic lesions
- decreased adiponectin level
- decreased cerebral infarction size
- decreased circulating alanine transaminase level
- decreased circulating aspartate transaminase level
- decreased circulating leptin level
- decreased digestive secretion
- decreased eosinophil cell number
- decreased inflammatory response
- decreased litter size
- decreased oligodendrocyte number
- decreased osteoclast cell number
- decreased survivor rate
- decreased susceptibility to endotoxin shock
- decreased susceptibility to induced choroidal neovascularization
- decreased susceptibility to induced colitis
- decreased susceptibility to injury
- decreased susceptibility to kidney reperfusion injury
- decreased systemic arterial systolic blood pressure
- decreased urine prostaglandin level
- decreased white adipose tissue amount
- delayed wound healing
- enhanced wound healing
- enlarged inguinal lymph nodes
- enlarged seminiferous tubules
- hyperlactation
- improved central nervous system regeneration
- improved glucose tolerance
- increased IgG2a level
- increased T cell proliferation
- increased body weight
- increased bone mineral density
- increased bone volume
- increased circulating antidiuretic hormone level
- increased circulating cholesterol level
- increased circulating creatinine level
- increased circulating prolactin level
- increased circulating triglyceride level
- increased compact bone mass
- increased food intake
- increased growth rate
- increased inflammatory response
- increased insulin sensitivity
- increased interferon-gamma secretion
- increased left ventricle developed pressure
- increased length of allograft survival
- increased mean systemic arterial blood pressure
- increased mortality induced by ionizing radiation
- increased myocardial infarction size
- increased renin activity
- increased sensitivity to induced morbidity/mortality
- increased single-positive T cell number
- increased sperm number
- increased susceptibility to bacterial infection
- increased susceptibility to experimental autoimmune encephalomyelitis
- increased susceptibility to parasitic infection
- increased susceptibility to pharmacologically induced seizures
- increased systemic arterial blood pressure
- increased systemic arterial systolic blood pressure
- increased testis weight
- increased urine pH
- liver fibrosis
- neuron degeneration
- pancreas inflammation
- premature death
- prolonged diestrus
- skin inflammation
role in cell
- ferroptosis
- production
- proliferation
- accumulation in
- expression in
- differentiation
- adhesion
- production in
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- insoluble fractions
- cortical cytoskeleton
- peroxisomal matrix
- intracellular compartment
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- Nucleus
- cytoplasmic aggregates
- cytosol
- primary cilia
- apical membrane
- nucleoplasm
- peroxisomes
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nos2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of guanylate cyclase activity
- negative regulation of protein catabolic process
- regulation of cytokine production involved in inflammatory response
- regulation of insulin secretion
- inflammatory response
- response to hypoxia
- peptidyl-cysteine S-nitrosylation
- defense response to Gram-negative bacterium
- nitric oxide mediated signal transduction
- negative regulation of blood pressure
- cell redox homeostasis
- circadian rhythm
- regulation of cellular respiration
- response to hormone stimulus
- defense response to bacterium
- regulation of cell proliferation
- arginine catabolic process
- negative regulation of gene expression
- response to bacterium
- positive regulation of interleukin-8 production
- innate immune response in mucosa
- superoxide metabolic process
- cellular response to lipopolysaccharide
- positive regulation of leukocyte mediated cytotoxicity
- response to lipopolysaccharide
- cellular response to xenobiotic stimulus
- cellular response to interferon-gamma
- nitric oxide biosynthetic process
- prostaglandin secretion
- positive regulation of interleukin-6 production
- positive regulation of killing of cells of other organism
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- peroxisomal matrix
- plasma membrane
- cortical cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- arginine binding
- calmodulin binding
- NADP binding
- tetrahydrobiopterin binding
- protein homodimerization activity
- protein binding
- nitric-oxide synthase activity
- FMN binding
- metal ion binding
- flavin adenine dinucleotide binding
- heme binding