Igf1 Gene Summary [Rat]
Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); borna disease; congenital diaphragmatic hernia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf1 |
| Official Name | insulin-like growth factor 1 [Source:RGD Symbol;Acc:2868] |
| Ensembl ID | ENSRNOG00000004517 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 1 |
| Synonyms | C730016P09Rik, IGF, IGF-I, IGF-I-smC, INSULIN-LIKE GROWTH FACTOR 1, insulin like growth factor I, insulin-like somatomedin peptide I, MAD isoform 4, mecasermin, mecasermin recombinant, MGF, Preproinsulin-like growth factor ia, somatomedin C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin like growth factor C domain
- insulin like growth factor D domain
- insulin receptor binding
- hormone
- protein binding
- cytokine
- insulin-like growth factor receptor binding
- growth factor
- steroid binding
- protein kinase activator
- kinase domain
- transmembrane receptor protein tyrosine kinase activator
- insulin like growth factor B domain
- insulin like growth factor A domain
- Insulin/IGF/Relaxin family
- integrin binding
- intracellular domain
- IlGF_like
- receptor agonist activity
Pathways
Biological processes and signaling networks where the Igf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Autophagy
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Clathrin-mediated Endocytosis Signaling
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- Huntington's Disease Signaling
- IGF-1 Signaling
- RhoA Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of NFAT in Cardiac Hypertrophy
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- gastric cancer
- cancer
- breast cancer
- non-small cell lung cancer
- HER2 negative hormone receptor negative breast cancer
- oral squamous cell carcinoma
- lung cancer
- breast carcinoma
phenotypes
- cardiac hypertrophy
- Albuminuria
- Alzheimer's Disease
- Brain Injuries
- Burns
- Carotid Artery Injuries
- Cockayne Syndrome
- Congenital Disorder of Glycosylation Type 1A
- Coronary Disease
- Deafness
- Diabetes Mellitus Experimental
- Diabetic Foot
- Diabetic Nephropathies
- Dwarfism
- Endotoxemia
- Experimental Arthritis
- Experimental Autoimmune Encephalomyelitis
- Experimental Liver Cirrhosis
- Fetal Growth Retardation
- Fetal Macrosomia
- Graves Ophthalmopathy
- Graves Disease
- Growth Disorders
- Head Injuries Closed
- Hearing Loss Noise-Induced
- Hearing Loss Sudden
- Henoch-Schoenlein purpura
- Huntington's Disease
- Hyperoxia
- Hyperphagia
- Hypoxia-Ischemia Brain
- Intervertebral Disc Displacement
- Knee Osteoarthritis
- Kuhnt-Junius degeneration
- Laron Syndrome
- Malocclusion
- Mammary Neoplasms Experimental
- Metabolic Bone Diseases
- Myocardial Ischemia
- Nasal Polyps
- Neointima
- Neoplasm Metastasis
- Noonan Syndrome
- Osteophytes
- Osteoporotic Fractures
- Oxygen-Induced Retinopathy
- PEHO Syndrome
- Plaque Atherosclerotic
- Postmenopausal Osteoporosis
- Prostatic Neoplasms
- Reperfusion Injury
- Rhinosinusitis
- Right Ventricular Hypertrophy
- Sarcopenia
- Skin Neoplasms
- Skull Fractures
- Stroke
- Thinness
- Tongue Neoplasms
- Turner Syndrome
- Wounds and Injuries
- Zinc Deficiency
- acne
- acoustic neuroma
- Alcoholic Neuropathy
- Alopecia
- Arteriosclerosis
- Brain Ischemia
- breast cancer
- carotid artery disease
- Cholestasis
- congenital diaphragmatic hernia
- Congenital Hypothyroidism
- congestive heart failure
- Coronary Stenosis
- Cystic Fibrosis
- Diabetes Mellitus
- diabetic neuropathy
- Diabetic Retinopathy
- dilated cardiomyopathy
- Familial Mediterranean Fever
- fetal alcohol spectrum disorder
- folic acid deficiency anemia
- granulomatosis with polyangiitis
- hypertension
- hypertrophic cardiomyopathy
- Hypothyroidism
- malignant glioma
- microcephaly
- Myocardial Infarction
- Myopia
- Non-alcoholic Fatty Liver Disease
- Osteoarthritis
- Osteoporosis
- pancreatic cancer
- pancreatic ductal carcinoma
- Polycystic Ovary Syndrome
- Progeria
- prostate carcinoma in situ
- psoriasis
- Pycnodysostosis
- Retinopathy of Prematurity
- Rheumatic Heart Disease
- transient cerebral ischemia
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- Uveal Melanoma
- vascular dementia
- Sudden Hearing Loss
- congenital disorder of glycosylation Ia
- Severe Acute Respiratory Syndrome
- Experimental Diabetes Mellitus
role in cell
- expression in
- quantity
- apoptosis
- proliferation
- colony formation
- cell death
- binding in
- migration
- number
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- glutaminergic synapse
- exocytic vesicle
- secretory granule lumen
- Cytoplasm
- cell surface
- Plasma Membrane
- vesicles
- endosomal compartment
- alpha granules
- extracellular matrix
- microsomal membrane
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of smooth muscle cell apoptotic process
- negative regulation of oocyte development
- negative regulation of interleukin-1 beta production
- myoblast differentiation
- positive regulation of Ras protein signal transduction
- positive regulation of mitosis
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of DNA binding
- positive regulation of glycogen biosynthetic process
- wound healing
- skeletal system development
- positive regulation of transcription regulatory region DNA binding
- positive regulation of transcription, DNA-dependent
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of cardiac muscle hypertrophy
- positive regulation of protein secretion
- positive regulation of epithelial cell proliferation
- negative regulation of tumor necrosis factor production
- muscle hypertrophy
- bone mineralization involved in bone maturation
- glycolate metabolic process
- insulin-like growth factor receptor signaling pathway
- Ras protein signal transduction
- positive regulation of activated T cell proliferation
- negative regulation of gene expression
- positive regulation of gene expression
- myotube cell development
- myoblast proliferation
- regulation of gene expression
- epithelial to mesenchymal transition
- positive regulation of cell growth involved in cardiac muscle cell development
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- cell proliferation
- positive regulation of glycoprotein biosynthetic process
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of glycolysis
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of smooth muscle cell proliferation
- response to heat
- positive regulation of fibroblast proliferation
- proteoglycan biosynthetic process
- satellite cell maintenance involved in skeletal muscle regeneration
- positive regulation of smooth muscle cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- activation of protein kinase B activity
- negative regulation of release of cytochrome c from mitochondria
- signal transduction
- positive regulation of glucose import
- positive regulation of MAPK cascade
- muscle organ development
- cell activation
- regulation of protein phosphorylation
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of extrinsic apoptotic signaling pathway
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- insulin-like growth factor binding protein complex
- exocytic vesicle
- platelet alpha granule lumen
- extracellular space
- alphav-beta3 integrin-IGF-1-IGF1R complex
- extracellular region
- insulin-like growth factor ternary complex
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- integrin binding
- insulin receptor binding
- hormone activity
- insulin-like growth factor receptor binding