Fzd9 Gene Summary [Rat]
Enables Wnt receptor activity. Involved in Wnt signaling pathway; postsynapse organization; and regulation of postsynaptic cytosolic calcium ion concentration. Is active in glutamatergic synapse and postsynapse. Orthologous to human FZD9 (frizzled class receptor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fzd9 |
| Official Name | frizzled class receptor 9 [Source:RGD Symbol;Acc:628817] |
| Ensembl ID | ENSRNOG00000001452 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 9 |
| Synonyms | CD349, frizzled class receptor 9, FZ-9, FZD3, mfz9, rFz9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Wnt binding domain
- Wnt-protein binding
- Frizzled/Smoothened family membrane region
- Wnt receptor
- Fz domain
- protein homodimerization
- seven-transmembrane G protein-coupled receptor superfamily
- protein heterodimerization
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Fzd9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- autism
- seizures
role in cell
- expression in
- proliferation
- apoptosis
- transformation
- phosphorylation in
- growth
- differentiation
- mineralization
- cell cycle progression
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- mitochondrial membrane
- membrane processes
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- G-protein coupled receptor signaling pathway
- cytosolic calcium ion homeostasis
- positive regulation of canonical Wnt receptor signaling pathway
- nervous system development
- negative regulation of neuron apoptotic process
- learning or memory
- negative regulation of necroptosis
- neuroblast proliferation
- ossification
- positive regulation of apoptotic process
- release of cytochrome c from mitochondria
- positive regulation of neural precursor cell proliferation
- canonical Wnt receptor signaling pathway
- regulation of cell cycle
- negative regulation of mitochondrial depolarization
- positive regulation of bone mineralization
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- mitochondrial membrane
- cytoplasm
- membrane
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- protein homodimerization activity
- protein heterodimerization activity
- Wnt-protein binding