Fzd9 Gene Summary [Mouse]

Enables Wnt receptor activity. Involved in several processes, including bone regeneration; negative regulation of skeletal muscle acetylcholine-gated channel clustering; and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within B cell differentiation; learning or memory; and neuroblast proliferation. Located in filopodium membrane and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; gonad; sensory organ; and skeleton. Used to study Williams-Beuren syndrome. Orthologous to human FZD9 (frizzled class receptor 9). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Fzd9
Official Name
frizzled class receptor 9 [Source:MGI Symbol;Acc:MGI:1313278]
Ensembl ID
ENSMUSG00000049551
Bio databases IDs NCBI: 14371 Ensembl: ENSMUSG00000049551
Aliases frizzled class receptor 9
Synonyms CD349, frizzled class receptor 9, FZ-9, FZD3, mfz9, rFz9
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fzd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • Wnt binding domain
  • Wnt-protein binding
  • Frizzled/Smoothened family membrane region
  • Wnt receptor
  • Fz domain
  • protein homodimerization
  • seven-transmembrane G protein-coupled receptor superfamily
  • protein heterodimerization
  • cysteine rich domain
  • CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • growth failure
  • autism
  • seizures
regulates
role in cell
  • expression in
  • proliferation
  • apoptosis
  • transformation
  • phosphorylation in
  • growth
  • differentiation
  • mineralization
  • cell cycle progression
  • number

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • Cytoplasm
  • cell surface
  • perinuclear region
  • postsynaptic region
  • cellular membrane
  • Golgi Apparatus
  • endoplasmic reticulum membrane
  • mitochondrial membrane
  • membrane processes
  • filopodia

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fzd9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • B cell differentiation
  • G-protein coupled receptor signaling pathway
  • cytosolic calcium ion homeostasis
  • positive regulation of canonical Wnt receptor signaling pathway
  • nervous system development
  • negative regulation of neuron apoptotic process
  • learning or memory
  • negative regulation of necroptosis
  • neuroblast proliferation
  • ossification
  • positive regulation of apoptotic process
  • release of cytochrome c from mitochondria
  • positive regulation of neural precursor cell proliferation
  • canonical Wnt receptor signaling pathway
  • regulation of cell cycle
  • negative regulation of mitochondrial depolarization
  • positive regulation of bone mineralization
  • non-canonical Wnt receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • filopodium membrane
  • endoplasmic reticulum membrane
  • perinuclear region of cytoplasm
  • mitochondrial membrane
  • cytoplasm
  • membrane
  • Golgi apparatus
  • plasma membrane
  • cell surface

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity
  • Wnt-activated receptor activity
  • protein homodimerization activity
  • protein heterodimerization activity
  • Wnt-protein binding

Gene-Specific Assays for Results You Can Trust

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