Spi1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of macromolecule biosynthetic process; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of DNA-templated transcription. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spi1 |
| Official Name | spleen focus forming virus (SFFV) proviral integration oncogene [Source:MGI Symbol;Acc:MGI:98282] |
| Ensembl ID | ENSMUSG00000002111 |
| Bio databases IDs | |
| Aliases | spleen focus forming virus (SFFV) proviral integration oncogene |
| Synonyms | AGM10, Dis-1, LOC100503306, LOC103691845, OF, PU.1, SFPI1, Spi-1 proto-oncogene, SPI-A, Tcfpu1, Tfpu.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- winged helix turn helix domain
- DNA binding domain
- nucleic acid binding
- TBP binding domain
- transcription activation domain
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein binding
- glutamine-rich domain
- sequence-specific DNA binding
- acidic domain
- DNA binding
- phosphorylation site
- PEST domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- ETS interacting domain
- Ets-domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Spi1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- hypertension
- fibrosis
- anemia
- neoplasia
- schizophrenia
- prostate cancer
- type M6 acute myeloid leukemia
- chronic kidney disease
- Alzheimer disease
phenotypes
- abnormal embryo size
- abnormal liver size
- preweaning lethality complete penetrance
- abnormal B cell differentiation
- abnormal B cell number
- abnormal T cell differentiation
- abnormal T cell number
- abnormal T cell subpopulation ratio
- abnormal astrocyte morphology
- abnormal blood cell morphology/development
- abnormal bone marrow morphology
- abnormal cell cycle
- abnormal chromosome number
- abnormal common myeloid progenitor cell morphology
- abnormal definitive hematopoiesis
- abnormal double-negative T cell morphology
- abnormal erythrocyte cell number
- abnormal erythropoiesis
- abnormal eye development
- abnormal fetal derived definitive erythrocyte cell number
- abnormal granulocyte morphology
- abnormal hematopoietic stem cell physiology
- abnormal hematopoietic system physiology
- abnormal leukopoiesis
- abnormal liver morphology
- abnormal macrophage differentiation
- abnormal microglial cell morphology
- abnormal monocyte morphology
- abnormal myelopoiesis
- abnormal neutrophil differentiation
- abnormal proerythroblast morphology
- abnormal spleen morphology
- absent B cells
- absent common myeloid progenitor cells
- absent mature B cells
- anemia
- arrested B cell differentiation
- decreased B cell number
- decreased B-1a cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased T cell number
- decreased body size
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased granulocyte number
- decreased hematocrit
- decreased hematopoietic stem cell number
- decreased macrophage cell number
- decreased mature B cell number
- decreased neutrophil cell number
- decreased pre-B cell number
- decreased pro-B cell number
- decreased spleen red pulp amount
- decreased thymocyte number
- enlarged liver
- enlarged spleen
- failure of myelopoiesis
- failure of tooth eruption
- impaired myelopoiesis
- increased B-1 B cell number
- increased B-1b cell number
- increased IgM level
- increased T cell derived lymphoma incidence
- increased T cell number
- increased bone marrow cell number
- increased double-negative T cell number
- increased granulocyte number
- increased hematopoietic stem cell number
- increased hematopoietic stem cell proliferation
- increased leukemia incidence
- increased liver weight
- increased lymphocyte cell number
- increased neutrophil cell number
- increased spleen weight
- increased tumor incidence
- lethality throughout fetal growth and development complete penetrance
- liver hyperplasia
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- osteopetrosis
- persistence of hyaloid vascular system
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality complete penetrance
- sepsis
- small thymus
- spleen hyperplasia
role in cell
- growth
- proliferation
- expression in
- apoptosis
- phosphorylation in
- activation in
- cell viability
- invasion
- invasion by
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oncogene-induced senescence
- positive regulation of gene expression, epigenetic
- negative regulation of NF-kappaB transcription factor activity
- regulation of transcription, DNA-dependent
- negative regulation of neutrophil degranulation
- pro-T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- myeloid leukocyte differentiation
- positive regulation of B cell differentiation
- regulation of erythrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
- regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of p38MAPK cascade
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- defense response to tumor cell
- negative regulation of transcription, DNA-dependent
- cell differentiation
- interleukin-6-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- sequence-specific DNA binding transcription factor activity
- RNA binding
- protein binding
- NFAT protein binding
- binding, bridging