PLXND1 Gene Summary [Human]
Enables protein domain specific binding activity. Predicted to be involved in several processes, including endothelial cell migration; nervous system development; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and positive regulation of protein binding activity. Located in lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | PLXND1 |
| Official Name | plexin D1 [Source:HGNC Symbol;Acc:HGNC:9107] |
| Ensembl ID | ENSG00000004399 |
| Bio databases IDs | |
| Aliases | plexin D1 |
| Synonyms | 6230425C21Rik, b2b1863Clo, b2b553Clo, CHTD9, PLEXD1, Plexin D1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLXND1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein domain specific binding
- protein binding
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- PDZ binding motif
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the PLXND1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- lichen planus
- multiple types congenital heart defects type 9
- flu
- peripheral arterial disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- cyanosis
role in cell
- number
- expression in
- apoptosis
- migration
- activation in
- collapse
- adhesion
- recognition
- collapse in
- retraction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- synaptic vesicles
- perikaryon
- axons
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLXND1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of cell adhesion
- outflow tract morphogenesis
- coronary vasculature development
- regulation of angiogenesis
- endothelial cell migration
- dichotomous subdivision of terminal units involved in salivary gland branching
- cardiac septum development
- negative regulation of neuron apoptotic process
- synaptic target recognition
- synapse assembly
- positive regulation of axonogenesis
- aorta development
- angiogenesis
- patterning of blood vessels
- kidney development
- regulation of GTPase activity
- regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- cell body
- plasma membrane
- axon
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- semaphorin receptor activity