RHOBTB1 Gene Summary [Human]
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | RHOBTB1 |
| Official Name | Rho related BTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18738] |
| Ensembl ID | ENSG00000072422 |
| Bio databases IDs | |
| Aliases | Rho related BTB domain containing 1 |
| Synonyms | 1700008H16Rik, 3110048G13RIK, LOC102555066, Rho-related BTB domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHOBTB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB_POZ
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- Broad-Complex, Tramtrack and Bric a brac
- Rab subfamily of small GTPases
- BTB/POZ domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RHOBTB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- T acute lymphoblastic leukemia
- COVID-19
- food allergy
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- pemphigus vulgaris
- myalgia
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHOBTB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment or maintenance of cell polarity
- actin filament organization
- Cdc42 protein signal transduction
- endocytosis
Cellular Component
Where in the cell the gene product is active
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity