GSKIP Gene Summary [Human]
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | GSKIP |
| Official Name | GSK3B interacting protein [Source:HGNC Symbol;Acc:HGNC:20343] |
| Ensembl ID | ENSG00000100744 |
| Bio databases IDs | |
| Aliases | GSK3B interacting protein, GSK3beta interaction protein |
| Synonyms | 4933433P14Rik, C14orf129, GSK3B interacting protein, HSPC210, RGD1308470 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSKIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GSK-3beta binding domain
- protein kinase A binding
- protein kinase binding
- protein kinase inhibitor activity
- protein binding
- GSKIP domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
- respiratory distress
- conotruncal heart malformations
- respiratory failure
- palatal shelves fail to meet at midline
- atelectasis
role in cell
- migration
- expression in
- proliferation
- binding in
- phosphorylation in
- frequency
- transcription in
- colony formation
- aggregation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSKIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of canonical Wnt receptor signaling pathway
- induction of apoptosis by oxidative stress
- regulation of Wnt receptor signaling pathway
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein kinase A regulatory subunit binding
- beta-catenin binding
- protein kinase inhibitor activity
- kinase regulator activity
- protein kinase A binding