WNT5B Gene Summary [Human]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
WNT5B
Official Name
Wnt family member 5B [Source:HGNC Symbol;Acc:HGNC:16265]
Ensembl ID
ENSG00000111186
Bio databases IDs NCBI: 81029 Ensembl: ENSG00000111186
Aliases Wnt family member 5B
Synonyms wingless-type MMTV integration site family, member 5B, Wnt family member 5B
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Wnt
  • wnt family
  • protein binding
  • receptor binding
  • found in Wnt-1

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • diabetic nephropathy
  • organismal death
  • familial obesity
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • osteoarthritis
  • squamous cell lung cancer
  • disorder of diaphragm
  • gout
regulated by
role in cell
  • expression in
  • accumulation in
  • proliferation
  • G1/S phase transition
  • differentiation
  • migration
  • invasion
  • number
  • phosphorylation in
  • hypertrophy

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Golgi lumen
  • endocytic vesicle membrane
  • cell surface
  • Plasma Membrane
  • endoplasmic reticulum lumen
  • extracellular matrix
  • exosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human WNT5B gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cellular response to retinoic acid
  • neuron differentiation
  • positive regulation of non-canonical Wnt receptor signaling pathway
  • muscle cell differentiation
  • cell fate commitment
  • chondrocyte differentiation
  • canonical Wnt receptor signaling pathway
  • fat cell differentiation
  • lens fiber cell development
  • positive regulation of cell migration

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum lumen
  • extracellular space
  • extracellular vesicular exosome
  • extracellular region
  • Golgi lumen
  • endocytic vesicle membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • frizzled binding
  • cytokine activity
  • receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.