Wnt5b Gene Summary [Rat]
Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; chondrocyte differentiation; and positive regulation of cell migration. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in extracellular space. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt5b |
| Official Name | Wnt family member 5B [Source:RGD Symbol;Acc:628850] |
| Ensembl ID | ENSRNOG00000008168 |
| Bio databases IDs | |
| Aliases | Wnt family member 5B |
| Synonyms | wingless-type MMTV integration site family, member 5B, Wnt family member 5B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt5b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- organismal death
- familial obesity
- lung adenocarcinoma
- lung adenocarcinoma formation
- osteoarthritis
- squamous cell lung cancer
- disorder of diaphragm
- gout
role in cell
- expression in
- accumulation in
- proliferation
- G1/S phase transition
- differentiation
- migration
- invasion
- number
- phosphorylation in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endocytic vesicle membrane
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to retinoic acid
- neuron differentiation
- positive regulation of non-canonical Wnt receptor signaling pathway
- muscle cell differentiation
- cell fate commitment
- chondrocyte differentiation
- canonical Wnt receptor signaling pathway
- fat cell differentiation
- lens fiber cell development
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
- Golgi lumen
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- cytokine activity
- receptor binding