UNC5A Gene Summary [Human]
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | UNC5A |
| Official Name | unc-5 netrin receptor A [Source:HGNC Symbol;Acc:HGNC:12567] |
| Ensembl ID | ENSG00000113763 |
| Bio databases IDs | |
| Aliases | unc-5 netrin receptor A |
| Synonyms | KIAA1976, mKIAA1976, UNC5H1, unc-5 netrin receptor A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UNC5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- extracellular domain
- PKC phosphorylation site
- immunoglobulin domain
- Immunoglobulin I-set domain
- UPA domain
- ZU5 domain
- PEST domain
- dileucine internalization motif
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- membrane-proximal domain
- Spondin-like TSP1 domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
- netrin receptor
Pathways
Biological processes and signaling networks where the UNC5A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- cytosol
- growth cone
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UNC5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- apoptotic process
- anterior/posterior axon guidance
- netrin-activated signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane raft
- neuronal cell body membrane
- plasma membrane
- neuron projection membrane
Molecular Function
What the gene product does at the molecular level
- netrin receptor activity