RNF146 Gene Summary [Human]
Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | RNF146 |
| Official Name | ring finger protein 146 [Source:HGNC Symbol;Acc:HGNC:21336] |
| Ensembl ID | ENSG00000118518 |
| Bio databases IDs | |
| Aliases | ring finger protein 146 |
| Synonyms | 2610509H23RIK, Iduna, ring finger protein 146 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF146 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- enzyme binding
- WWE domain
- enzyme
- Ring finger domain
- protein binding
- Domain in Deltex and TRIP12 homologues
- binding protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
role in cell
- expression in
- proliferation
- autophagy in
- accumulation in
- degradation in
- signaling in
- response by
- BI-2536 sensitivity
- ubiquitination in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF146 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding