IL17C Gene Summary [Human]
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | IL17C |
| Official Name | interleukin 17C [Source:HGNC Symbol;Acc:HGNC:5983] |
| Ensembl ID | ENSG00000124391 |
| Bio databases IDs | |
| Aliases | interleukin 17C |
| Synonyms | CX2, interleukin 17C, LOC687591 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL17C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interleukin-17
- cytokine
Pathways
Biological processes and signaling networks where the IL17C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colorectal neoplasia
- gastrointestinal neoplasia
- hyperplasia
- psoriasis
- experimental autoimmune encephalomyelitis
- peroxisomal acyl CoA oxidase deficiency
- colon neoplasm
- experimental hepatitis
- small intestine neoplasm
role in cell
- proliferation
- expression in
- production in
- number
- differentiation
- cellular infiltration by
- survival
- immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL17C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cell-cell signaling
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- cytokine activity