ITGA9 Gene Summary [Human]
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITGA9 |
| Official Name | integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145] |
| Ensembl ID | ENSG00000144668 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 9, integrin, alpha 4-like |
| Synonyms | 2610002H11Rik, 6720458D17RIK, (alpha)9, ALPHA-RLC, D130073C02, D9Ertd428e, integrin alpha 9, integrin subunit alpha 9, integrin subunit α 9, Integrin α 9, ITGA4L, Itga9l, LOC687154, RLC, (α)9, α-RLC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITGA9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha (beta-propellor repeats)
- extracellular domain
- Integrin alpha
- cytoplasmic domain
- laminin binding
- cell adhesion molecule binding
- integrin binding
- transmembrane domain
- collagen binding
- protein binding
- FG-GAP repeat
- FG-GAP-like repeat
Pathways
Biological processes and signaling networks where the ITGA9 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- T-cell non-Hodgkin disease
- liver cancer
- oral squamous cell carcinoma
- hepatocellular carcinoma
- liver metastasis
- schizophrenia
- cervical cancer
- nasopharyngeal neoplasm
role in cell
- phosphorylation in
- expression in
- formation
- proliferation
- number
- accumulation
- loss
- loss in
- migration
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITGA9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- negative regulation of vasoconstriction
- neutrophil chemotaxis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- external side of plasma membrane
- integrin complex
- plasma membrane
- alpha9-beta1 integrin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- integrin binding