TP53INP1
TP53INP1 Gene Summary
Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TP53INP1 |
| Official Name | tumor protein p53 inducible nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:18022] |
| Ensembl ID | ENSG00000164938 |
| Bio databases IDs | |
| Aliases | tumor protein p53 inducible nuclear protein 1 |
| Synonyms | 2700057G22Rik,DKFZp434M1317,p53DINP1,P53INP1,SIP,STINP,Teap,Thymus Expressed Acidic,TP53DINP1,TP53DINP1alpha,TP53INP1A,TP53INP1B,transformation related protein 53 inducible nuclear protein 1,Trp53inp1,tumor protein p53 inducible nuclear protein 1,tumour protein p53 inducible nuclear protein 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DOR family
- antioxidant enzyme
- protein binding
Pathways
Biological processes and signaling networks where the TP53INP1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ASPM
- TP53
- SQSTM1
- E2F1
- ZBTB9
- ELAVL1
- GABARAPL2
- UNC119
- MAP1LC3A
- HNRNPL
disease
- neoplasia
- hepatic steatosis
- epithelial neoplasia
- hyperglycemia
- weight gain
- adenoma formation
- benign neoplasia
- prostate cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
regulated by
- SLC40A1
- TNF
- cisplatin
- CD24
- FTO-IT1
- E2F1
- doxorubicin
- MCPH1
- IL2
- INHA
regulates
- SNAI1
- TP53
- SPARC
- BAX
- CDKN1A
- Ins1
- SMAD2/3
- CDH1
- ascorbic acid
- MDM2
role in cell
- expression in
- phosphorylation in
- apoptosis
- migration
- cell death
- cell cycle progression
- proliferation
- function
- differentiation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- autophagic vacuoles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TP53INP1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- autophagic vacuole assembly
- cellular response to ethanol
- negative regulation of gene expression
- positive regulation of autophagy
- response to heat
- positive regulation of transcription, DNA-dependent
- negative regulation of fibroblast proliferation
- positive regulation of gene expression
- autophagic cell death
- positive regulation of apoptotic process
- apoptotic process
- cellular response to UV
- cellular response to hydroperoxide
- regulation of cell cycle
- cellular response to methyl methanesulfonate
- negative regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- antioxidant activity