VEGFD Gene Summary [Human]
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | VEGFD |
| Official Name | vascular endothelial growth factor D [Source:HGNC Symbol;Acc:HGNC:3708] |
| Ensembl ID | ENSG00000165197 |
| Bio databases IDs | |
| Aliases | vascular endothelial growth factor D |
| Synonyms | C-FOS-INDUCED GROWTH FACTOR, FIGF, VASCULAR ENDOTHELIAL GROWTH FACTOR D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VEGFD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VEGF homology domain
- PDGF
- chemoattractant
- platelet-derived growth factor receptor binding
- protein binding
- vascular endothelial growth factor receptor binding
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the VEGFD gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Bladder Cancer Signaling
- Clathrin-mediated Endocytosis Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Estrogen Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- metastasis
- COVID-19
- idiopathic pulmonary fibrosis
- non-small cell lung carcinoma
- non-small cell lung cancer
- memory deficits
- plaque psoriasis
- hypoplasia
role in cell
- expression in
- phosphorylation in
- activation in
- differentiation
- migration
- proliferation
- adhesion
- chemotaxis
- formation
- mitogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VEGFD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- positive regulation of cell proliferation
- vascular endothelial growth factor signaling pathway
- sprouting angiogenesis
- positive regulation of angiogenesis
- positive regulation of mast cell chemotaxis
- fibroblast proliferation
- vascular endothelial growth factor receptor signaling pathway
- response to bacterium
- response to hypoxia
- positive regulation of cell division
- dopaminergic neuron differentiation
- positive regulation of protein phosphorylation
- positive regulation of endothelial cell proliferation
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- growth factor activity
- protein binding
- vascular endothelial growth factor receptor binding
- platelet-derived growth factor receptor binding
- vascular endothelial growth factor receptor 3 binding
- chemoattractant activity