RBM38 Gene Summary [Human]
Enables mRNA 3'-UTR binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of RNA metabolic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RBM38 |
| Official Name | RNA binding motif protein 38 [Source:HGNC Symbol;Acc:HGNC:15818] |
| Ensembl ID | ENSG00000132819 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 38 |
| Synonyms | dJ800J21.2, HSRNASEB, KW5, RNA binding motif protein 38, RNPC1, Seb4, SEB4B, SEB4D, Seb4l, Seb4-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- hepatic steatosis
- ulceration
- liver neoplasia
role in cell
- proliferation
- expression in
- senescence
- premature senescence
- differentiation
- number
- G1 phase
- abnormal morphology
- destabilization in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of RNA splicing
- cell differentiation
- regulation of myotube differentiation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA 3'-UTR binding