IL1RL2 Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | IL1RL2 |
| Official Name | interleukin 1 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:5999] |
| Ensembl ID | ENSG00000115598 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor like 2 |
| Synonyms | IL-1 R6, IL1RRP2, IL-36R, interleukin 1 receptor-like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL1RL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- cytokine receptor
- TIR domain
- interleukin-1 receptor
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the IL1RL2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Dendritic Cell Maturation
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- allergic asthma
- neoplasia
- ulcerative colitis
- psoriatic lesion
- hidradenitis suppurativa
- generalized pustular psoriasis
- psoriasis
- Crohn disease
- Netherton syndrome
role in cell
- proliferation
- growth
- expression in
- activation in
- production in
- migration
- binding in
- phosphorylation in
- differentiation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL1RL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- inflammatory response
- signal transduction
- innate immune response
- positive regulation of T cell differentiation
- regulation of inflammatory response
- interleukin-1-mediated signaling pathway
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- interleukin-1 receptor activity
- interleukin-1, Type I, activating receptor activity