IRF7 Gene Summary [Human]
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | IRF7 |
| Official Name | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] |
| Ensembl ID | ENSG00000185507 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 7 |
| Synonyms | IFNRG7A, IMD39, interferon regulatory factor 7, IRF7A, IRF7C, IRF-7H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Sumoylation motif
- regulatory domain
- DNA binding domain
- nucleic acid binding
- IRF
- Irf binding domain
- signal response domain
- transcription activation domain
- Interferon-regulatory factor 3
- inhibitory domain
- PP1 binding domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the IRF7 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Neuroinflammation Signaling Pathway
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- TGF-β Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsing-remitting multiple sclerosis
- systemic lupus erythematosus
- metastasis
- COVID-19
- Huntington disease
- lung cancer
- anemia
- immunodeficiency 39
- colorectal cancer
- glomerulonephritis
role in cell
- formation in
- expression in
- cell death
- apoptosis
- phosphorylation in
- recruitment in
- killing
- activation in
- replication in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- endosomes
- cytosol
- endosomal compartment
- endosomal membrane
- nucleoplasm
- early endosomes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- negative regulation of transcription from RNA polymerase II promoter
- cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of interferon-alpha production
- establishment of viral latency
- positive regulation of transcription, DNA-dependent
- positive regulation of interferon-beta production
- regulation of MyD88-independent toll-like receptor signaling pathway
- defense response to virus
- regulation of MyD88-dependent toll-like receptor signaling pathway
- negative regulation of macrophage apoptotic process
- regulation of adaptive immune response
- regulation of immune response
- positive regulation of type I interferon production
- MDA-5 signaling pathway
- regulation of monocyte differentiation
- response to DNA damage stimulus
- immune system process
- regulation of transcription from RNA polymerase II promoter
- type I interferon-mediated signaling pathway
- innate immune response
- immunoglobulin mediated immune response
- regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endosome membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity