WNT7B Gene Summary [Human]
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | WNT7B |
| Official Name | Wnt family member 7B [Source:HGNC Symbol;Acc:HGNC:12787] |
| Ensembl ID | ENSG00000188064 |
| Bio databases IDs | |
| Aliases | Wnt family member 7B |
| Synonyms | wingless-type MMTV integration site family, member 7B, Wnt family member 7B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT7B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- chemoattractant
- wnt family
- receptor agonist activity
- protein binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT7B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- osteoarthritis
- bleeding
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- colorectal cancer
- syndromic anophthalmia and microphthalmia
- breast carcinoma
role in cell
- proliferation
- quantity
- expression in
- differentiation
- number
- signaling in
- organization
- invasion by
- morphogenesis
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cell periphery
- Plasma Membrane
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNT7B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lobar bronchus development
- developmental growth involved in morphogenesis
- embryonic placenta morphogenesis
- lung epithelium development
- central nervous system vasculogenesis
- positive regulation of osteoblast differentiation
- forebrain regionalization
- lung morphogenesis
- fibroblast proliferation
- in utero embryonic development
- stem cell proliferation
- response to glucocorticoid stimulus
- mammary gland epithelium development
- metanephric collecting duct development
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- oxygen homeostasis
- establishment or maintenance of polarity of embryonic epithelium
- lens fiber cell development
- metanephric epithelium development
- lung development
- synapse organization
- neuron differentiation
- embryonic organ development
- inner medullary collecting duct development
- chorio-allantoic fusion
- outer medullary collecting duct development
- trachea cartilage morphogenesis
- renal outer medulla development
- renal inner medulla development
- metanephros morphogenesis
- cellular response to retinoic acid
- positive regulation of JNK cascade
- homeostatic process
- cell fate commitment
- metanephric loop of Henle development
- regulation of cell projection size
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- Golgi lumen
- extracellular region
- plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity