IGHG1
IGHG1 Gene Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Predicted to act upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of hypersensitivity; and positive regulation of phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHG1 |
| Official Name | immunoglobulin heavy constant gamma 1 (G1m marker) [Source:HGNC Symbol;Acc:HGNC:5525] |
| Ensembl ID | ENSG00000211896 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant gamma 1 (G1m marker) |
| Synonyms | Gamma1,IGG1,IgG gamma 1 heavy chain,IGG KAPPA HEAVY CHAIN,IgG γ 1 heavy chain,IGG κ HEAVY CHAIN,IGH-4,IG HEAVY CONSTANT gamma 1 (G1M MARKER),IG HEAVY CONSTANT γ 1 (G1M MARKER),Immunoglobulin gamma-1 heavy chain,Immunoglobulin GL Gamma 1,Immunoglobulin GL γ 1,immunoglobulin heavy constant gamma 1 (G1m marker),immunoglobulin heavy constant γ 1 (G1m marker),Immunoglobulin γ-1 heavy chain,VH7183 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH2 domain (from immunoglobulin)
- binding protein
- CH3 domain (from immunoglobulin)
- hinge domain
- heavy chain domain, constant
- antigen binding
- protein binding
- receptor binding
- Fc domain
Pathways
Biological processes and signaling networks where the IGHG1 gene plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- IL-7 Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ALB
- YWHAG
- RNF115
- PDLIM7
- FCGR1A
- PINK1
- OR2A4
- YWHAZ
- UBE2H
- KYAT1
disease
- neoplasia
- diabetes mellitus
- Alzheimer disease
- insulin resistance
- airway hyperresponsiveness
- lung cancer
- prostate cancer
- psoriatic arthritis
- psoriasis
- rheumatoid arthritis
regulated by
- lipopolysaccharide
- VIP
- prostaglandin E2
- TGFB1
- STAT5B
- phenytoin
- aspirin
- TNFSF13B
- IL5
- CD38
regulates
- ERK1/2
- Scd1
- TNF
- IL10
- IL4
- MMP13
- VEGFA
- IL6
- IFNG
- Ca2+
role in cell
- phosphorylation in
- quantity
- growth
- apoptosis
- production in
- proliferation
- accumulation
- differentiation
- cell viability
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IGHG1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- complement-dependent cytotoxicity
- antibody-dependent cellular cytotoxicity
- complement activation, classical pathway
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- immunoglobulin complex, circulating
- extracellular region
- plasma membrane
- IgG immunoglobulin complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- antigen binding
- Fc-gamma receptor I complex binding
- immunoglobulin receptor binding