Kif26a Gene Summary [Mouse]
Enables microtubule binding activity. Involved in enteric nervous system development; negative regulation of signal transduction; and regulation of cell growth by extracellular stimulus. Predicted to be located in cytoplasm and microtubule. Is expressed in central nervous system; ganglia; and intestine. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif26a |
| Official Name | kinesin family member 26A [Source:MGI Symbol;Acc:MGI:2447072] |
| Ensembl ID | ENSMUSG00000021294 |
| Bio databases IDs | |
| Aliases | kinesin family member 26A |
| Synonyms | CDCBM11, kinesin family member 26A, LOC684940, LOC688273, mKIAA1236 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif26a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- megacolon
- growth failure
- complex cortical dysplasia with other brain malformations
- complex cortical dysplasia with other brain malformations 11
- organismal death
- cachexia
- hereditary spastic paraplegia
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- expression in
- migration
- proliferation
- binding in
- development
- invasion by
- growth by
- migration by
- outgrowth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif26a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- enteric nervous system development
- negative regulation of signal transduction
- cerebral cortex development
- regulation of neuron projection development
- regulation of cell growth by extracellular stimulus
- microtubule-based movement
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding