Supt20 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Acts upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. Is expressed in several structures, including gut. Orthologous to human SUPT20H (SPT20 homolog, SAGA complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supt20 |
| Official Name | SPT20 SAGA complex component [Source:MGI Symbol;Acc:MGI:1929651] |
| Ensembl ID | ENSMUSG00000027751 |
| Bio databases IDs | |
| Aliases | SPT20 SAGA complex component |
| Synonyms | AI450544, C13, C13orf19, D3Ertd300e, FAM48A, FP757, P38IP, RGD1307812, SPT20, SPT20 homolog, SAGA complex component, SPT20 SAGA complex component, Supt20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supt20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Spt20 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- susceptibility to rheumatoid arthritis
role in cell
- expression in
- phosphorylation in
- production in
- binding in
- formation
- formation in
- phagocytosis by
- deubiquitination in
- gluconeogenesis in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supt20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- regulation of RNA splicing
- autophagy
- gastrulation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- SAGA-type complex
- SAGA complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity