Anks1b Gene Summary [Mouse]
Predicted to enable ephrin receptor binding activity. Involved in chemical postsynaptic transmission. Acts upstream of or within regulation of synaptic plasticity by receptor localization to synapse. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anks1b |
| Official Name | ankyrin repeat and sterile alpha motif domain containing 1B [Source:MGI Symbol;Acc:MGI:1924781] |
| Ensembl ID | ENSMUSG00000058589 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms | AIDA, AIDA-1, ANKS2, ankyrin repeat and sterile alpha motif domain containing 1B, ankyrin repeat and sterile α motif domain containing 1B, C030032C09Rik, cajalin-2, E530015N03Rik, EB-1, Gm10937, Gm1555, RGD1565556 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anks1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Ankyrin repeats (many copies)
- SAM (Sterile alpha motif )
- SAM domain
- SAM domain (Sterile alpha motif)
- Ankyrin repeats (3 copies)
- ephrin receptor binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- acute myeloid leukemia
- bipolar I disorder
- COVID-19
- bipolar disorder
- schizophrenia
- insomnia
- amyotrophic lateral sclerosis
- attention deficit hyperactivity disorder
- major depression
role in cell
- survival
- synaptic transmission in
- maturation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- organelle
- cell cortex
- Plasma Membrane
- centrosome
- nucleoplasm
- synapse
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anks1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ephrin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- centrosome
- dendritic spine
- Cajal body
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ephrin receptor binding