Robo3 Gene Summary [Mouse]
Involved in axon midline choice point recognition and commissural neuron axon guidance. Acts upstream of or within neuron migration. Located in axon. Is expressed in several structures, including central nervous system; cranial nerve; future brain; head mesenchyme; and sensory organ. Orthologous to human ROBO3 (roundabout guidance receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Robo3 |
| Official Name | roundabout guidance receptor 3 [Source:MGI Symbol;Acc:MGI:1343102] |
| Ensembl ID | ENSMUSG00000032128 |
| Bio databases IDs | |
| Aliases | roundabout guidance receptor 3 |
| Synonyms | HGPPS, HGPPS1, HGPS, RBIG1, RIG1, Robo3a, Robo3b, Robo3 (predicted), roundabout guidance receptor 3, Roundabout homolog 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Robo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Robo3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial horizontal gaze palsy with progressive scoliosis type 1
- preeclampsia
- organismal death
- gaze palsy
- endometriosis
- hereditary disorder
- gestational diabetes mellitus
- granulocytosis
- familial horizontal gaze palsy with progressive scoliosis
role in cell
- production in
- expression in
- induction in
- proliferation
- migration
- guidance
- crossover
- development
- tumorsphere formation by
- contact repulsion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Robo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- dendrite self-avoidance
- axon guidance
- axon midline choice point recognition
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding