Slitrk5 Gene Summary [Mouse]
Involved in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including grooming behavior; neuron projection morphogenesis; and positive regulation of synapse assembly. Is active in postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and neural retina. Orthologous to human SLITRK5 (SLIT and NTRK like family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slitrk5 |
| Official Name | SLIT and NTRK-like family, member 5 [Source:MGI Symbol;Acc:MGI:2679448] |
| Ensembl ID | ENSMUSG00000033214 |
| Bio databases IDs | |
| Aliases | SLIT and NTRK-like family, member 5 |
| Synonyms | 2610019D03RIK, bA364G4.2, LRCC11, LRRC11, SLIT and NTRK like family member 5, SLIT and NTRK-like family, member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slitrk5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- obsessive-compulsive disorder
- thyroid carcinoma
- epithelial thyroid cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- density
- morphology
- development
- morphogenesis
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slitrk5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- grooming behavior
- axonogenesis
- circulatory system development
- synaptic transmission
- response to xenobiotic stimulus
- striatum development
- positive regulation of synapse assembly
- skin development
- adult behavior
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- receptor complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding