Zdhhc9 Gene Summary [Mouse]
Predicted to enable Ras palmitoyltransferase activity. Involved in positive regulation of pyroptotic inflammatory response. Acts upstream of or within non-canonical inflammasome complex assembly and protein maturation. Predicted to be located in Golgi membrane and cytosol. Predicted to be part of palmitoyltransferase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in cerebral cortex ventricular layer and cortical plate. Used to study syndromic X-linked intellectual disability Raymond type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Orthologous to human ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc9 |
| Official Name | zinc finger, DHHC domain containing 9 [Source:MGI Symbol;Acc:MGI:2444393] |
| Ensembl ID | ENSMUSG00000036985 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 9 |
| Synonyms | 6430508G22, 9530098M12Rik, CGI89, CXorf11, DHHC9, MMSA1, MRXSR, MRXSZ, ZDHHC10, zinc finger, DHHC domain containing 9, zinc finger DHHC-type palmitoyltransferase 9, ZNF379, ZNF380 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- hypotonia
- diabetic nephropathy
- hereditary disorder
- organismal death
- Raymond type syndromic X-linked mental retardation
- androgenic alopecia
- HER2 negative hormone receptor negative breast cancer
- mental retardation
- membranous glomerulonephritis
role in cell
- glycolysis in
- expression in
- production in
- proliferation
- binding in
- function
- palmitoylation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- peptidyl-L-cysteine S-palmitoylation
- protein palmitoylation
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- palmitoyltransferase complex
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- Ras palmitoyltransferase activity
- palmitoyltransferase activity