Sema3d Gene Summary [Mouse]
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Located in extracellular space. Is expressed in several structures, including alimentary system; foot mesenchyme; intraembryonic coelom; nervous system; and sensory organ. Orthologous to human SEMA3D (semaphorin 3D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3d |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [Source:MGI Symbol;Acc:MGI:1860118] |
| Ensembl ID | ENSMUSG00000040254 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D |
| Synonyms | 4631426B19Rik, coll-2, LOC246262, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D, semaphorin 3D, Sema-Z2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- Immunoglobulin like
- Sema domain
- Immunoglobulin V-set domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- primary hyperparathyroidism
- total anomalous pulmonary venous return
- cachexia
- atrial septal defect
- parathyroid hyperplasia
role in cell
- proliferation
- expression in
- activation in
- phosphorylation in
- migration
- outgrowth
- loss
- colony formation by
- collapse
- chemorepulsion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding