Gzmk Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in granzyme-mediated programmed cell death signaling pathway and protein maturation. Predicted to be active in extracellular space. Is expressed in several structures, including eye; forebrain; lung; small intestine; and spleen. Orthologous to human GZMK (granzyme K). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gzmk |
| Official Name | granzyme K [Source:MGI Symbol;Acc:MGI:1298232] |
| Ensembl ID | ENSMUSG00000042385 |
| Bio databases IDs | |
| Aliases | granzyme K |
| Synonyms | Granzyme 3, GRANZYME K, NK-tryptase-2, TRYP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gzmk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- serine-type peptidase
- peptidase
- Domain of unknown function (DUF1986)
- protein binding
Pathways
Biological processes and signaling networks where the Gzmk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- sepsis
- early missed abortion
- systemic autoimmune syndrome
- Waldenström macroglobulinemia
- diabetic nephropathy
- systemic sclerosis
- psoriasiform dermatitis
- septic shock
- sporadic amyotrophic lateral sclerosis
role in cell
- proliferation
- cell death
- transmembrane potential
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gzmk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity