Mat2a Gene Summary [Mouse]
Enables methionine adenosyltransferase activity. Acts upstream of or within S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; liver and biliary system; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mat2a |
| Official Name | methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731] |
| Ensembl ID | ENSMUSG00000053907 |
| Bio databases IDs | |
| Aliases | methionine adenosyltransferase II, alpha |
| Synonyms | AdoMet Synthetase alpha2, D630045P18Rik, MAT 2, MATA2, MATII, methionine adenosyltransferase 2A, S-ADENOSYLMETHIONINE SYNTHETASE, SAMS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mat2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-adenosylmethionine synthetase, central domain
- binding protein
- S-adenosylmethionine synthetase, C-terminal domain
- ATP binding
- S-adenosylmethionine synthetase
- enzyme
- protein binding
- identical protein binding
- methionine adenosyltransferase
- S-adenosylmethionine synthetase, N-terminal domain
- amino acid binding
Pathways
Biological processes and signaling networks where the Mat2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostatic carcinoma
- epithelial cancer
- colorectal cancer
- liver cancer
- experimental autoimmune encephalomyelitis
- coronary artery disease
- prostate cancer
- angina pectoris
- osteosarcoma
role in cell
- expression in
- survival
- cell viability
- synthesis in
- apoptosis
- differentiation
- morphology
- migration
- formation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mat2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to methionine
- protein hexamerization
- protein heterooligomerization
- S-adenosylmethionine biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- methionine adenosyltransferase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- small molecule binding
- methionine adenosyltransferase activity