Lta Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lta |
| Official Name | lymphotoxin alpha [Source:RGD Symbol;Acc:3020] |
| Ensembl ID | ENSRNOG00000000838 |
| Bio databases IDs | |
| Aliases | lymphotoxin alpha |
| Synonyms | hlb382, LOC103690381, LT, LT-alpha, Ltx, LT-α, LYMPHOTOXIN A, lymphotoxin alpha, lymphotoxin α, TNFB, TNF-beta, TNFSF1, Tnfsf1b, TNF-β, TNLG1E, tumor necrosis factor-β, tumour necrosis factor-beta, tumour necrosis factor-β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF homology domain
- tumor necrosis factor receptor binding
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Lta gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Adrenomedullin signaling pathway
- CD40 Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- Lymphotoxin β Receptor Signaling
- NF-κB Signaling
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- TNFR2 Signaling
- TREM1 Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- active rheumatoid arthritis
- rheumatoid arthritis
- non-Hodgkin disease
- follicular B-cell or T-cell lymphoma
- metastasis
- cancer
- bleeding
- infection
- epithelial neoplasia
- liver cancer
role in cell
- binding
- phosphorylation in
- proliferation
- expression in
- quantity
- cell death
- apoptosis
- growth
- formation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of glial cell proliferation
- cell-cell signaling
- response to nutrient
- lymph node development
- response to xenobiotic stimulus
- response to hypoxia
- positive regulation of chronic inflammatory response to antigenic stimulus
- negative regulation of fibroblast proliferation
- positive regulation of interferon-gamma production
- humoral immune response
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of humoral immune response mediated by circulating immunoglobulin
- response to lipopolysaccharide
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding