Dvl3 Gene Summary [Rat]
Enables signaling receptor binding activity. Involved in positive regulation of neuron projection arborization and response to xenobiotic stimulus. Predicted to be located in chromatin and cytoplasm. Predicted to be part of Wnt signalosome. Predicted to be active in cytosol and glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dvl3 |
| Official Name | dishevelled segment polarity protein 3 [Source:RGD Symbol;Acc:1308834] |
| Ensembl ID | ENSRNOG00000001708 |
| Bio databases IDs | |
| Aliases | dishevelled segment polarity protein 3 |
| Synonyms | b2b2866Clo, dishevelled segment polarity protein 3, DRS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dvl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- Domain present in PSD-95, Dlg, and ZO-1/2
- DIX domain
- frizzled binding
- protease binding
- beta-catenin binding
- protein binding activity, bridging
- canonical PDZ domain
- enzyme binding
- protein binding
- receptor binding
- PDZ domain
- Segment polarity protein dishevelled (Dsh) C terminal
- DEP
- Dishevelled specific domain
- cpPDZ_Deg_HtrA-like
Pathways
Biological processes and signaling networks where the Dvl3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- neoplasia
- colorectal cancer
- autosomal dominant Robinow syndrome type 2
- adenocarcinoma
- epithelial cancer
- organismal death
- persistent truncus arteriosus
- transposition of great vessel
- dyspnea
role in cell
- expression in
- phosphorylation in
- migration
- growth
- invasion by
- transcription in
- orientation
- organization
- flow by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
- synapse
- chromatin
- perikaryon
- dendritic knobs
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dvl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- planar cell polarity pathway involved in neural tube closure
- regulation of protein localization
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- regulation of actin cytoskeleton organization
- positive regulation of transcription, DNA-dependent
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- protein stabilization
- non-canonical Wnt receptor signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- small GTPase binding
- protease binding
- beta-catenin binding
- receptor binding