Adcy5 Gene Summary [Rat]
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and heart development. Located in endosome and sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy5 |
| Official Name | adenylate cyclase 5 [Source:RGD Symbol;Acc:71014] |
| Ensembl ID | ENSRNOG00000002229 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 5 |
| Synonyms | AC5, Ac type V, adenylate cyclase 5, Adenylyl Cyclase5, DSKOD, FDFM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C1A domain
- Adenylyl cyclase N-terminal extracellular and transmembrane region
- enzyme
- protein binding
- Adenylate cyclase, conserved domain
- C2 domain (from adenylate cyclase)
- cytoplasmic domain
- adenylate cyclase binding
- adenylate cyclase
- C2II subdomain (from adenylate cyclase)
- calcium/calmodulin-responsive adenylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- C1 domain (from adenylate cyclase)
- C2I subdomain (from adenylate cyclase)
Pathways
Biological processes and signaling networks where the Adcy5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- COVID-19
- chronic obstructive pulmonary disease
- familial dyskinesia with facial myokymia
- hereditary disorder
- hepatocellular carcinoma
- Huntington disease
- diabetic retinopathy
role in cell
- apoptosis
- phosphorylation in
- production in
- long term synaptic depression
- response by
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cellular membrane
- endosomes
- primary cilia
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- regulation of insulin secretion involved in cellular response to glucose stimulus
- adenosine receptor signaling pathway
- adenylate cyclase-activating dopamine receptor signaling pathway
- locomotory behavior
- adenylate cyclase-inhibiting dopamine receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- neuromuscular process controlling balance
- intracellular signal transduction
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- scaffold protein binding
- metal ion binding
- adenylate cyclase binding
- adenylate cyclase activity