Sos2 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sos2 |
| Official Name | SOS Ras/Rho guanine nucleotide exchange factor 2 [Source:RGD Symbol;Acc:620435] |
| Ensembl ID | ENSRNOG00000004826 |
| Bio databases IDs | |
| Aliases | SOS Ras/Rho guanine nucleotide exchange factor 2 |
| Synonyms | mSOS-2, NS9, Sos1, SOS Ras/Rho guanine nucleotide exchange factor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sos2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- RhoGEF
- catalytic domain
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- RasGEF
- Pleckstrin homology-like domain
- REM
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Sos2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- EGF Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Gαi Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-2 Signaling
- IL-7 Signaling Pathway
- Integrin Signaling
- JAK/Stat Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- PAK Signaling
- Paxillin Signaling
- PDGF Signaling
- PPAR Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renal Cell Carcinoma Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- hypertension
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- male infertility
- Noonan syndrome type 9
- Noonan syndrome type 1
- renal failure
- systemic lupus erythematosus
- Noonan syndrome
role in cell
- proliferation
- expression in
- differentiation
- activation in
- phosphorylation in
- cell viability
- number
- accumulation
- migration
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- Plasma Membrane
- endosomes
- cytosol
- growth cone
- neurites
- synaptosomes
- early endosomes
- filopodia
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sos2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- positive regulation of small GTPase mediated signal transduction
- insulin receptor signaling pathway
- regulation of pro-B cell differentiation
- Ras protein signal transduction
- regulation of T cell differentiation in thymus
- B cell homeostasis
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- guanyl-nucleotide exchange factor activity