Prkch Gene Summary [Rat]
Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in phospholipase C/protein kinase C signal transduction and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human PRKCH (protein kinase C eta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkch |
| Official Name | protein kinase C, eta [Source:RGD Symbol;Acc:621888] |
| Ensembl ID | ENSRNOG00000004873 |
| Bio databases IDs | |
| Aliases | protein kinase C, eta |
| Synonyms | MGC5363, nPKC-eta, Pkc Eta, Pkch, PKC-L, PRKCL, protein kinase C eta, protein kinase C, eta, uORF2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- Defence against restriction A N-terminal
- Protein kinase domain
- translation regulator
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- alcohol group acceptor phosphotransferase
- protein kinase C
- Tyrosine kinase, catalytic domain
- C2 domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- calcium independent protein kinase C
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase inhibitor
- Protein Kinases, catalytic domain
- pseudosubstrate domain
- C1B domain
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the Prkch gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- ErbB4 Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neoplasia
- myocardial infarction
- epithelial cancer
- epithelial neoplasia
- rheumatoid arthritis
- venous thromboembolism
- acute coronary syndrome
- B-cell non-Hodgkin disease
- tumorigenesis
role in cell
- cell death
- apoptosis
- size
- proliferation
- expression in
- growth
- molecular cleavage in
- activation in
- number
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Plasma Membrane
- intercellular junctions
- cytosol
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- protein kinase C signaling cascade
- signal transduction
- cellular response to amino acid starvation
- positive regulation of glial cell proliferation
- negative regulation of glial cell apoptotic process
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of B cell receptor signaling pathway
- cell differentiation
- positive regulation of translation in response to stress
- regulation of tight junction assembly
- positive regulation of macrophage derived foam cell differentiation
- negative regulation of protein serine/threonine kinase activity
- peptidyl-serine phosphorylation
- negative regulation of translation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cell-cell junction
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium-independent protein kinase C activity
- protein serine/threonine kinase inhibitor activity
- translation regulator activity
- protein binding
- metal ion binding
- small GTPase binding
- protein kinase activity
- protein serine/threonine kinase activity
- protein kinase C activity
- enzyme binding