Camp Gene Summary [Rat]
Predicted to enable lipopolysaccharide binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cytokine production; and response to bacterium. Located in cell projection and extracellular space. Biomarker of dentin caries and pancreatitis. Orthologous to human CAMP (cathelicidin antimicrobial peptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camp |
| Official Name | cathelicidin antimicrobial peptide [Source:RGD Symbol;Acc:1559878] |
| Ensembl ID | ENSRNOG00000020733 |
| Bio databases IDs | |
| Aliases | cathelicidin antimicrobial peptide |
| Synonyms | Antibacterial protein Fall-39 precursor, CAP-18, CAP-18/LL-37, CATHELICIDIN, cathelicidin antimicrobial peptide, Cathelin-related antimicrobial peptide, CATHL4, CLP, Cnlp, CRAMP, FALL-39, hCAP-18, HSD26, MCLP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cathelin-like domain
- Cathelicidin
- protein binding
- LPS binding domain of CAP18 (C terminal)
Pathways
Biological processes and signaling networks where the Camp gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Pancreas Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- FXR/RXR Activation
- Gαi Signaling
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
- TR/RXR Activation
- VDR/RXR Activation
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- epithelial cancer
- cancer
- liver cancer
- endotoxemia
- atopic dermatitis
- neoplasia
- plaque psoriasis
- colon cancer
- systemic lupus erythematosus
role in cell
- binding
- apoptosis
- formation
- production in
- expression in
- activation in
- cell death
- transmembrane potential
- maturation
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- cell surface
- Extracellular Space
- organelle lumens
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- granules
- lysosomal compartment
- endosomal compartment
- mast cell secretory granules
- early endosomes
- late endosomes
- specific granules
- membrane rafts
- cellular protrusions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytolysis
- neutrophil activation
- defense response to Gram-negative bacterium
- positive regulation of cell proliferation
- defense response to bacterium
- positive regulation of angiogenesis
- killing by host of symbiont cells
- innate immune response in mucosa
- cellular response to interleukin-6
- cellular response to lipopolysaccharide
- innate immune response
- positive regulation of protein phosphorylation
- cellular response to interleukin-1
- antibacterial humoral response
- cellular response to peptidoglycan
- cellular response to tumor necrosis factor
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- specific granule
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding