Pla2g4b Gene Summary [Rat]
Predicted to enable calcium ion binding activity; calcium-dependent phospholipid binding activity; and phospholipase activity. Predicted to be involved in glycerophospholipid catabolic process; phosphatidylcholine acyl-chain remodeling; and phosphatidylethanolamine acyl-chain remodeling. Predicted to be located in early endosome membrane and mitochondrial inner membrane. Predicted to be active in cytosol. Orthologous to several human genes including PLA2G4B (phospholipase A2 group IVB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g4b |
| Official Name | phospholipase A2 group IVB [Source:RGD Symbol;Acc:1308658] |
| Ensembl ID | ENSRNOG00000007447 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IVB |
| Synonyms | A030011C02Rik, cPLA2-beta, cPLA2-β, Gm1013, HsT16992, phospholipase A2 group IVB, phospholipase A2, group IVB (cytosolic) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Patatins and Phospholipases
- lysophospholipase
- phospholipase A1
- Cytosolic phospholipases A2 C2-domain
- Lysophospholipase catalytic domain
- calcium-dependent phospholipase A2
- enzyme
- Protein kinase C conserved region 2 (CalB)
- phospholipase A2
- C2 domain
Pathways
Biological processes and signaling networks where the Pla2g4b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
- mitochondrial inner membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- glycerophospholipid catabolic process
- calcium-mediated signaling
- phosphatidylglycerol acyl-chain remodeling
- arachidonic acid metabolic process
- parturition
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- cytosol
- extracellular region
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- lysophospholipase activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phosphatidylcholine 1-acylhydrolase activity
- calcium-dependent phospholipid binding