Pak6 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to starvation; intracellular signal transduction; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm and postsynaptic density. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK6 (p21 (RAC1) activated kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pak6 |
| Official Name | p21 (RAC1) activated kinase 6 [Source:RGD Symbol;Acc:1306213] |
| Ensembl ID | ENSRNOG00000007925 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 6 |
| Synonyms | 4732456M09, p21 (RAC1) activated kinase 6, PAK5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pak6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mitochondrial presequence
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- nuclear export signal
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- CRIB
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Pak6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- neoplasia
- schizophrenia
- COVID-19
role in cell
- expression in
- apoptosis
- invasion
- organization
- abnormal morphology
- formation
- outgrowth
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cell junction
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pak6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- locomotory behavior
- cytoskeleton organization
- apoptotic process
- regulation of transcription, DNA-dependent
- learning
- protein phosphorylation
- memory
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- cytosol
- cell junction
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cadherin binding
- protein serine/threonine kinase activity